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Not only does Oprah Winfrey’s basic cable network OWN have lack-luster ratings, but now the mogul is losing part of her Harpo Studios’ star power.

According to FOX411.com, Jenny McCarthy has parted ways with Winfrey who signed her to a development deal in 2009. McCarthy has instead jumped over to NBC.

FOX 411.com reports that after a difference of opinion over how to handle McCarthy’s new TV series, McCarthy took the project elsewhere to produce.

“Jenny wasn’t thrilled with the direction that OWN producers were going with on the show,” a source revealed. “She had been working with Oprah and her producers for over a year, developing this project for OWN. Jenny finally decided to embrace Oprah’s philosophy, which is to ‘follow your bliss.’ Well, Jenny followed her bliss and walked right off the project.”

According Us Weekly, a rep for Winfrey’s Harpo Studios said the studio and McCarthy mutually agreed to part ways and that the project was not in development at OWN as reported.

Losing McCarthy and her new series is surely a blow to Winfrey, who developed a friendship with the actress through her work as an advocate for children with autism. McCarthy also penned a blog for Oprah.com.

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